Pegylated nanoparticles for encapsulation of bisnaphthalimidopropyl derivatives against Leishmania infantum
نویسندگان
چکیده
1 IBMC-INEB, Biology of Infection an Immunology Division Parasite Disease Group. Rua do Campo Alegre, 823, 4150-180 Porto, Portugal 2 CIQUP Departamento de Química, Faculdade de Ciências, 4169 – 007 Porto, Portugal 3 School of Life Sciences, The Robert Gordon University, Aberdeen AB29 9SB, Scotland, UK 4 Faculdade de Farmácia da Universidade do Porto, Laboratório de Bioquímica. Rua Aníbal Cunha, 164, 4050-047 Porto, Portugal
منابع مشابه
Bisnaphthalimidopropyl derivatives as inhibitors of Leishmania SIR2 related protein 1.
The NAD(+)-dependent deacetylases, namely sirtuins, are involved in the regulation of a variety of biological processes such as gene silencing, DNA repair, longevity, metabolism, apoptosis, and development. An enzyme from the parasite Leishmania infantum that belongs to this family, LiSIR2RP1, is a NAD(+)-dependent tubulin deacetylase and an ADP-ribosyltransferase. This enzyme's involvement in ...
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